The toxicity of barley
toxicity 1. Acute toxicity: The mice were intragastrically indigo 32g/kg and indirubin 25g/kg, which did not cause animal death. Indigo and indirubin were given as LD50 by intraperitoneal injection of 2.20±0.23g/kg and 1.11±, respectively. 0.14g/kg. The LD50 of mice injected intraperitoneally was 1.1-2.0 g/kg. The mice were intragastrically administered 5 g/kg for 5 consecutive days and observed for 1 week. No animals died and no significant toxicity was observed. 2. Subacute Toxicity: Rats ingested indirubin daily 500g/kg, no weight, blood was observed for one month; bone marrow, liver function, electrocardiogram change. Toxicity: Intraperitoneal injection of indirubin has a LD50 of 1310±140 mg/kg in mice. Indirubin 200mg/kg gavage, continuous 1 month, can make rats hepatocytes swelling and degeneration, nuclear and nucleoli hypertrophy, intragastric administration for 6 months, hepatocytes swelling, soluble ring death and atrophy . Long-term administration had no significant effect on normal hematopoietic cell formation in mice, rats and guinea pigs. Dogs were infused with indirubin 20, 100, 200 mg/kg for 6 consecutive months. The results showed that the appetite and growth of the low-dose group were similar to that of the control group, while the animals in the large- and medium-dose groups showed decreased appetite and diarrhea after taking the drug. Blood in the stool and SGPT elevation and focal hepatocyte necrosis and other reactions. However, the blood and bone marrow images of the three dose groups were not significantly inhibited, and they had no effect on renal function and electrocardiogram. Freeze Dried Strawberries,Dehydrated Strawberries,Freeze Dried Strawberries Bulk,Strawberry Dry Fruit Shanghai Sinospices Sourcing Ltd , https://www.garlicall.com