Accurate localization and precise operation of brain tumors by near-infrared fluorescence bimodal image navigation
Release date: 2015-09-17 Helping to guide the precise surgical resection of the tumor can greatly improve the prognosis of patients, and has very important clinical application prospects. Source: Bio 360
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Recently, scientists have developed a new type of magnetic resonance/near-infrared two-zone fluorescence bimodal imaging nanoprobe (Gd-Ag2S nanoprobe) consisting of Ag2S near-infrared quantum dots and Gd-DOTA coupled to its surface. Gd-based high tissue penetration depth magnetic resonance contrast enhanced imaging and high signal-to-noise ratio based on Ag2S quantum dots and high spatial-temporal resolution near-infrared two-region fluorescence imaging for preoperative diagnosis and intraoperative glioma Precision resection provides a "visualization" solution. After intravenous injection, due to the abundant neovascularization and EPR effect in the tumor area, magnetic resonance imaging of in situ high-contrast brain tumors is realized, and the optical characteristics of the near-infrared region of Ag2S quantum dots are used to achieve accurate imaging of glioma vessels. Precise resection of microscopic tumors at sub-millimeter scales.
Based on this "Detection" and "Operation" collaborative strategy to identify tumor boundaries that are unrecognizable to the naked eye, it is expected to provide real-time navigation for future clinical brain surgery, to achieve accurate tumor location and precise surgery, and to reduce normal tissue and functional damage.
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Original Search: Preoperative Detection and Intraoperative Visualization of Brain Tumors for More Precise Surgery: A New Dual-Modality MRI and NIR Nanoprobe