Chinese Academy of Engineering Cao Xuetao: Antiviral immune cells "switch" found
"How do natural immune cells respond once they recognize a virus invading"? The team of Chinese Academy of Engineering Cao Xuetao found that DNA methylase Dnmt3a can make natural immune cells highly sensitive to viral infections. Once the virus is invaded, it can significantly produce interferon and initiate antiviral natural immune response. The findings were published in the British journal Nature-Immunology. In order to clarify why natural immune cells have a rapid resistance to "virus invasion", the research team first allowed natural immune cells to infect viruses, analyzed the molecular expression changes of infected cells, and chose to be able to determine gene expression by regulating DNA methylation. The epigenetic regulatory molecule is a breakthrough point. After screening, it was found that DNA methylase Dnmt3a can promote the efficient release of type I interferon by natural immune cells. "The genome-wide DNA of the natural immune cells was subsequently obtained, and the methylation on the DNA strand was clarified at a single nucleotide level, and the 'spectrum' was drawn. Based on this spectrum, we conducted a mechanism study." Cao Xuetao said He and Li Xia, Ph.D. student of Zhejiang University Institute of Immunology, and Zhang Qian, State Key Laboratory of Medical Immunology, Institute of Immunology, Second Military Medical University, found that the specific path of action is: Dnmt3a binds to the distal promoter region of HDAC9 and maintains DNA in this region. Hypermethylation, which antagonizes H3K27me3 in this region, promotes the level of activated histone modification of the proximal promoter to maintain high expression of HDAC9. The highly expressed HDAC9 further efficiently induces type I interferon production through a certain mechanism to initiate an antiviral natural immune response. Studies have shown that DNA methylation can maintain high expression of key molecules in the antiviral signal transduction pathway, preparing natural cells for timely and efficient initiation of antiviral immune responses during viral invasion. This discovery reveals a novel epigenetic mechanism of antiviral immune response and a new potential molecular target for the prevention and treatment of viral infectious diseases. Cosmetic Additives,Cosmetic Whitening Ingredients,Cosmetic Antioxidant Agent,Anti Aging Additive Allied Extracts Solutions , https://www.alliedadditives.com