Medical Network March 21, scientists at Monash University are farther away from the goal of developing an oral contraceptive combination to suppress sperm delivery during ejaculation, and this hormone-free male contraceptive will soon become a reality in the future.
A hormone-free contraceptive will completely avoid the side effects that currently hinder the development of male contraceptives. These side effects usually come from interference with male hormones, which can cause long-term irreversible effects on pregnancy, childbirth, etc.
Previous studies by this group of scientists have shown that simultaneous removal of two proteins that promote sperm trafficking (α1A adrenergic receptors and P2X1 purinergic receptors) can achieve male infertility without affecting the long-term activity and normal life of male sperm. . Sperm is effective, but muscles cannot accept the chemical signals that reach it.
In fact, there are already drugs approved for long-term inhibition of individual proteins in two proteins, but researchers are now trying to develop an oral contraceptive to inhibit two proteins.
Fund support from Monash University's contraceptive initiative has enabled scientists at the Monash Institute of Pharmaceutical Sciences to conduct further research, but they also need other funding to speed up the study.
Lead researcher Dr. Sab Ventura said that if the next step in drug development is successful, then clinical trials will begin, and it is likely that the first hormone-free reversible male contraceptive will be available in the next 5-10 years.
“We are getting closer and closer to a convenient, safe, effective and hormone-free male contraceptive,†Dr. Ventura said.
"We want to inhibit the transport of sperm by combining two drugs, rather than disturbing the development and maturation of sperm."
Dr. Ventura said genetic studies have shown that sperm are still healthy , but their transport is suppressed after taking the drug, sexual desire and sexual activity are still normal.
"Past strategies have focused primarily on hormonal targeting or mechanisms that prevent sperm abnormalities from becoming pregnant, but these methods can also interfere with male sexual behavior and cause long-term irreversible effects," Dr. Ventura said.
"If you have this hormone-free drug, the sperm will not be affected, which means that once you stop the drug, fertility can be restored."
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