Lancet: Progress in Ebola Vaccine Research

Lancet: Progress in Ebola Vaccine Research

September 27, 2018 Source: Ministry of Science and Technology

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On August 19th, an article in Lancet magazine summarized the current research and clinical trials in the field of Ebola virus vaccines, and proposed important knowledge gaps that need to be resolved in future research. According to Clinicaltrials.gov, there are currently 36 clinical trials of the Ebola vaccine, and another 14 are ongoing. The experimental vaccine for the Rvsv-ZEBOV virus has been practiced in the Congo. By summarizing the studies of four other Ebola virus test vaccines (Ad26.ZEBOV, MVA-BN-Filo, chAd3-EBO-Z and GamEvac-Combi), the authors proposed areas that should be studied in the future. Specifically, experts have suggested that more research data on pregnant women, children, and immunodeficiency groups are needed, as well as research data on older populations with HIV. At the same time, the authors suggest that there is more evidence to prove the protective effect of the vaccine (ie whether the above vaccine can awaken the body's immune response, thus freeing the individual from Ebola virus infection), and requires large-scale clinical trials to explore its safety. Sex and effectiveness. The authors say that research in the social sciences will greatly assist in the design of relevant clinical trials. They believe that it is necessary to study the effects of different types of vaccines and vaccination strategies on possible future outbreaks. The achievement of these goals requires the collaboration of relevant scientists on a global scale.

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