The study found that some of the bacterial resistance genes are the same as antibiotics.

The study found that some of the bacterial resistance genes are the same as antibiotics.

June 19, 2017 Source: Xinhua News Agency

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Antibiotic abuse leads to the emergence and widespread spread of drug-resistant germs, and where do the genes that make these germs resistant? For the first time, Danish researchers have confirmed a long-standing conjecture in the scientific community: the bacteria that produce antibiotics to germs are the bacteria that produce antibiotics.

The press release issued by the Technical University of Denmark recently said that the researchers in the school compared the gene sequences of some common pathogens and various actinomycetes, and found that the drug resistance genes are very similar, and some even the same, indicating that the pathogen is These genes are obtained from actinomycetes.

Actinomycetes are a large class of bacteria that are mainly found in the soil and can produce a variety of antibiotics. At least three-quarters of the antibiotics currently used by humans are from actinomycetes. Previously, the scientific community has found that actinomycetes themselves carry genes that are resistant to antibiotics. The new study is the first to confirm that the resistance genes of pathogens are from actinomycetes.

Gene exchange between the same kind of bacteria is very common, but these pathogens are very different from actinomycetes, and the genetic relationship is far away. How is the gene transfer between them realized? The researchers suggest that this may involve a previously unknown transfer mechanism, which they call "gene return."

Medical waste or farm waste contaminates the soil, giving the bacteria access to actinomycetes. The bacteria invade the DNA (deoxyribonucleic acid) into the actinomycetes through the bacterial bonding process, and recombine with the DNA containing the drug resistance gene in the actinomycete genome. After the actinomycetes die, the recombined DNA enters the surrounding environment, and the above-mentioned pathogen DNA can act as a "glue", bringing the resistance gene back into the genome of the pathogen.

Researchers report in the UK's new issue of Nature Newsletter that they have experimentally demonstrated that this type of gene transfer is indeed possible. They believe that although gene transfer cannot be stopped, understanding the drug resistance genes that may be carried by the bacteria can help doctors develop more targeted antibiotic therapies and help people develop new antibiotics that overcome the resistance of the bacteria.

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