Rice cultivation differs in occurrence of bastard disease
Macrolide antibiotics
Tylosin
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Seed soaking before sowing is an effective measure to prevent bastard disease. Applicable drugs include cynomodin, fludioxonil, ethyl allicin, and prochloraz. However, if the dose is too low or the drug concentration is too low, it will lead to a decrease in the control effect and cause bastard disease. Too short to soak seeds for medicinal purposes can also lead to a decrease in control effectiveness. In some areas, rice bakanae pathogens have developed resistance to prochloraz. In these areas, it is better to use cyanogenate, ethyl allicin, and fludioxonil for soaking. During soaking of rice, pathogenic bacteria on diseased seeds can contaminate disease-free seeds. Bacillus mucilaginosus mainly infects buds during germination. At this time, the rice seeds are piled, and the temperature and humidity are suitable. The conidia carried by some rice species germinate in large quantities, not only infecting the original rice seedlings, but also infecting the original pathogens. Contaminated rice seeds have greatly increased the infection rate. Generally, germination is more severe than non-germination. The longer the germination time, the heavier the disease. After soaking the seeds with medicine, it can effectively control bakanae disease without germination or rushing to whitening. Studies have shown that shortening the time for soaking germination also has a significant preventive effect on bastard disease, with direct sowing of dried seeds being the most obvious. Compared with soaking and pregerminating, the direct seeding of dry seeds can control more than 80% of the disease strains of bastard disease.
The occurrence of bastard disease in transplanted and machine-planted paddy fields is relatively heavy, which may be related to improper selection and soaking of seeds, poor seed soaking quality, and long germination time. Dry direct seeding of rice, generally sowing dried seeds, does not germinate, the bacteria infection rate is low, even if there are some bacteria seeds, pathogens generally will not infect the healthy seedlings, and thus the incidence of light or no disease.
It is a kind of weakly basic antibiotics produced or semi synthesized by Streptomyces. It has 14-16 membered cyclolactone structure.
Shared by human and animal: erythromycin, kitasamycin and Spiramycin
Special for animals: tylosin, tevancomycin, tilmicosin, tylosin, gemicin and tilmicosin
Physical and chemical properties
Weakly alkaline, slightly soluble in water. It is easy to decompose in aqueous solution, especially in acidic condition.
All preparations are salted with inorganic acids, such as phosphoric acid (tylosin, tilmicosin), tartaric acid (tylosin, kitasamycin), thiocyanic acid (erythromycin, erythromycin for animals), lactose acid (erythromycin), and hydrochloric acid (spiramycin).
Antibacterial action
The antibacterial spectrum is narrow: it has antibacterial effect on G + bacteria and some G - bacteria; It has good effect on some spirochetes, chlamydia, mycoplasma and Rickettsia; To produce β- Staphylococcus aureus and Staphylococcus aureus have certain antibacterial activity.
It is usually an antibacterial drug, which can kill bacteria at high concentration.
Special for animals, tartrate (oral), phosphate (premix)
Pharmacology: it has strong effect on G + bacteria and mycoplasma, but weak effect on G - bacteria; It can promote the growth of cattle, pigs and chickens.
Application: it is effective to prevent and cure mycoplasma infection of swine and poultry. The premix can promote the growth.
Preparation: tylosin tartrate soluble powder
Tylosin for injection and Tylosin Injection
Tylosin phosphate premix
Tylosin phosphate + sulfamethazine premix
2. Clinical application
In the pig industry, tylosin is the first choice for the prevention and treatment of swine asthma caused by mycoplasma infection. It can also treat swine dysentery, atrophic rhinitis, arthritis, leptospirosis and so on.
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