The pharmacological effects of Cistanche
Pharmacological effects 1. Anti-aging research shows that: Cistanche has a certain degree of anti-aging effects. Cistanche can significantly increase the activity of superoxide dismutase (SOD) in mouse erythrocytes and reduce the content of myocardial lipofuscin in mice. It can also extend the average lifespan, half-life and maximum lifespan of fruit flies. Cistanbus decoction 8g/kg gavage mice can significantly increase the activity of Na+, K+-ATPase in erythrocyte membrane, which may be one of the mechanisms of its tonic effect. Cistanche alcohol extracts were given to mice by gavage, daily 2.5 to 31.25 g (crude drug)/Kg for 18 consecutive days, which could significantly increase the activity of superoxide dismutase of red blood cells and decrease the content of lipofuscin in myocardial tissue. May extend the life expectancy, maximum life span, and half mortality of fruit flies. In addition, the product also has laxative, antihypertensive, antimutagenic and other effects. 2. Adjusting Endocrine, Promoting Metabolism and Strengthening Effects Cistanche can adjust the decrease and increase of hepatic and spleen nucleic acid content in Yang deficiency and yin deficiency animals; it can activate the adrenal glands and release corticosteroids. Its mechanism of action may be to enhance the hypothalamic-pituitary-ovarian luteal function, not because they directly stimulate the secretion of pituitary luteinizing hormone, but to improve the pituitary response to LRH and ovarian response to LH. It is suggested that the main significance of traditional Chinese medicine for tonifying the kidney is to improve the regulation mechanism in the body, and to play an active therapeutic role through the restoration of the internal function of the body itself. Through studies on the effect of Cistanche on the DNA synthesis rate of animals with "yang deficiencies", it was found that hydroxyurea causes a decrease in the rate of DNA synthesis due to its inhibition of the reduction of nucleotides at the level of diphosphorylation, resulting in a disorder of protein and energy metabolism that causes "yang deficiency". "Citrus brevifolia may contain a bioactive factor that activates ribonucleotide reductase, which can significantly increase the DNA synthesis rate of "yang deficiency" animals and promote the synthesis of RNA; increase the nucleic acid metabolism of the protein; and use its dilute ethanol extract to join Feeding rats in drinking water can promote growth and development. Cistanche decoction 10 g/kg gavage can enhance the function of hypothalamus-pituitary-ovarian in rats, increase pituitary response to luteinizing hormone-releasing hormone and ovarian response to luteinizing hormone without affecting the natural reproductive cycle. Endocrine balance. 3. Effects on the immune system Cistanche water extract 50mg/kg, 100mg/kg gavage to mice, can significantly increase the weight of the spleen and thymus, and can significantly enhance peritoneal macrophage phagocytosis, increased hemolysin and PFC values, Increased lymphocyte transformation rate and delayed hypersensitivity index, can also increase cAMP levels, reduce cGMP levels, increase cAMP/cGMP ratio, which may be one of the reasons for its enhanced peritoneal macrophage phagocytosis. Cistanche ethanol extract 1.25g/kg, 2.5g/kg (equivalent to crude drug 5.61g/kg, 11.21g/kg) gavage mice for 8 days, the fifth day of sensitization with sheep red blood cells, can significantly inhibit the spleen The number of plaques in the cell. Cistanche extract and total flavonoids of Epimedium have an additive effect on promoting the immune system of immune suppressing mice, which can enhance the immune ability of model mice. Cistanche decoction 50, 100mg/kg gavage for 7 consecutive days, the mice thymus, spleen weight gain, peritoneal macrophage phagocytic activity increased, serum hemolysin antibody and splenocytes hemolytic plaques increased, peripheral blood of mice Increased conversion rate, 3H-TdR incorporation into lymphocytes, delayed hypersensitivity to mice also increased. 4. To promote DNA synthesis: Cistanche decoction (0.5g/ml) 0.5ml / only gavage, caused by hydrocortisone acetate "yang deficiency" mice, can increase its liver and spleen DNA synthesis. 5. Other effects of Cistanche water leaching solution, ethanol - water leaching solution and alcohol leaching solution have an antihypertensive effect on anesthetized dogs, cats, rabbits, etc. Cistanche has an effect of promoting saliva secretion and respiratory palsy in mice and promoting salivary secretion as an organic acid-like substance. The components of respiratory palsy may be fleas. 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