Model NO.: CAS 130-89-2
Tren Acetate character: White Powder
Tren A Assay: 99%
Molecular Formula: C20H25ClN2O2
Molecular Weight: 360.87800
Usage: Antimalarial
Grade: Pharmaceutical Grade
Delivery Time: 1 working day after payment received
Payment Terms: T/T, Western Union, Money Gram, Bitcoin
Package: Foil bag package
Supply ability: 2000kg/month and more
Trademark: ZZYC
Transport Package: Foil Bag, or as Your Demand
Specification: 25kg/drum
Origin: China
Model NO.: CAS 130-89-2
Tren Acetate character: White Powder
Tren A Assay: 99%
Molecular Formula: C20H25ClN2O2
Molecular Weight: 360.87800
Usage: Antimalarial
Grade: Pharmaceutical Grade
Delivery Time: 1 working day after payment received
Payment Terms: T/T, Western Union, Money Gram, Bitcoin
Package: Foil bag package
Supply ability: 2000kg/month and more
Trademark: ZZYC
Transport Package: Foil Bag, or as Your Demand
Specification: 25kg/drum
Origin: China
Raw Quinine hydrochloride powder for Antimalarial use
Product name: Quinine hydrochloride
Alias: PYRAZINE-2-CARBOXAMIDINE HYDROCHLORIDE; QUININE HYDROCHLORIDE DIHYDRATE; QUININE HCL; QUININEHCL; QUININEHYDROCHLORIDE;
CAS Number: 130-89-2
Molecular formula: C20H25ClN2O2
Molecular weight: 360.87800
Density: 1.21g/cm3
Melting point: 158-160oC
Boiling point: 495.9oC at 760mmHg
Flash point: 253.7oC
Refractive index: 1.638
Steam pressure: 0mmHg at 25°C
Packing level: III
Hazard Category: 6.1(b)
Customs code: 2939200000
Dangerous goods transport code: UN 1544
Hazard category code: R36/37/38
Safety instructions: S26; S36
Dangerous Goods Sign: Xi
Quinine is a quinoline derivative and has a strong killing effect on various erythrocytic schizonts of Plasmodium. It can combine with Plasmodium DNA to form complexes, inhibit DNA replication and RNA transcription, thereby inhibiting the protein synthesis of protozoa, but the effect is weaker than chloroquine. It can also reduce the oxygen consumption of Plasmodium, inhibit the phosphorylase in Plasmodium and interfere with its sugar metabolism. It also causes agglutination of malarial pigments, but it develops slowly and rarely forms large clumps. In the blood, a certain concentration of Quinine can lead to premature rupture of the parasitized red blood cells, thus preventing the schizont from maturing. Quinine has no effect on the infrared phase and does not cure benign malaria. A long course of treatment can cure P. falciparum, but it has no direct effect on the gametophyte of P. falciparum, so it cannot interrupt transmission. In addition, Quinine has an inhibitory effect on the myocardium, prolongs the refractory period, slows conduction, and weakens its contractility. There is a weak excitatory effect on the uterus during pregnancy.
Effect
Quinine is an important antimalarial drug for the erythrocytic protozoa of P. falciparum that inhibits its reproduction or kills it. Quinine also inhibits myocardial contractility and increases uterine rhythmic contraction.
Quinine COAÂ
Product name
|
Quinine Hydrochloride Dihydrate
|
CAS No.
|
6119-47-7
|
Outer Packing
|
25KG
|
Production date
|
2017.05.24
|
Shelf life
|
2019.05.23
|
Standard adopted
|
BP 2010
|
Items of analysis
|
Specification
|
Results
|
Appearance
|
White, off-white or colorless fine needle crystal
|
Complies
|
Solubility
|
Soluble in water, slightly soluble in ethanol
|
Complies
|
Thin layer chromatography
|
The position, color and size of the points obtained by the experimental solution are consistent with the standard solution.
|
Complies
|
Color reaction
|
Solution green
|
Complies
|
Fluorescence reaction
|
Strong blue fluorescence at 366nm, disappeared after adding 1ml of hydrochloric acid
|
Complies
|
Infrared spectrum
|
The infrared absorption spectrum of this product should be consistent with the reference spectrum (spectrum set 488)
|
Complies
|
Solution appearance
|
The solution is colorless. If there is hydrochloric acid, it is not deeper than GY6.
|
Complies
|
PH
|
6.0-6.8
|
6.4
|
Specific rotation
|
-245°~ -258°
|
-248.3°
|
Other quinine
|
Impurity C ≤ 10.0%,
|
5.17%
|
Any impurities before quinidine ≤5.0%
|
1.12%
|
Sulfate
|
≤500ppm
|
Complies
|
Boron
|
Should be complied
|
Complies
|
Loss on drying
|
6.0%-10.0%
|
7.11%
|
Sulphate ash
|
≤0.1%
|
0.06%
|
Assay (dry product)
|
99.0%-101.0%
|
99.1%
|
Conclusion
|
Qualified
|
Pregnant women are disabled, quinine has oxytocin, can pass the placenta, causing fetal hearing damage and congenital defects of the central nervous system, limbs. Nursing women with caution.
For patients with asthma, atrial fibrillation and other severe heart diseases, glucose-6-phosphate dehydrogenase deficiency, myasthenia gravis, and optic neuritis should be used with caution.
Cardiomyopathy and pregnant women are disabled. Treatment of cerebral malaria with quinine is dangerous, and it is dangerous for people who are allergic to quinine.
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Â
Â
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Rimonaban* (CAS: 158681-13-1)
Â
Local Anaesthetic Drug
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Tetracaina hydrochloride (CAS:136-47-0)
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Â
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Estradiol (CAS: 50-28-2)Â
Estriol (CAS:50-27-1)
Estradiol valerate (CAS: 979-32-8)
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Hexestrol (CAS:84-16-2)
Â
others
Proscar (CAS: 98319-26-7)
Avodart (CAS: 164656-23-9)
Androstan-17-ol, 2,3-epithio-17-methyl-, (2a,3a,5a,17b)- (CAS:4267-80-5)
Estra-4,9-diene-3,17-dione (CAS:5173-46-6)
Methoxydienone (CAS:2322-77-2)
Altrenogest (CAS:850-52-2)Â
Raw Quinine hydrochloride powder for Antimalarial use
Product name: Quinine hydrochloride
Alias: PYRAZINE-2-CARBOXAMIDINE HYDROCHLORIDE; QUININE HYDROCHLORIDE DIHYDRATE; QUININE HCL; QUININEHCL; QUININEHYDROCHLORIDE;
CAS Number: 130-89-2
Molecular formula: C20H25ClN2O2
Molecular weight: 360.87800
Density: 1.21g/cm3
Melting point: 158-160oC
Boiling point: 495.9oC at 760mmHg
Flash point: 253.7oC
Refractive index: 1.638
Steam pressure: 0mmHg at 25°C
Packing level: III
Hazard Category: 6.1(b)
Customs code: 2939200000
Dangerous goods transport code: UN 1544
Hazard category code: R36/37/38
Safety instructions: S26; S36
Dangerous Goods Sign: Xi
Quinine is a quinoline derivative and has a strong killing effect on various erythrocytic schizonts of Plasmodium. It can combine with Plasmodium DNA to form complexes, inhibit DNA replication and RNA transcription, thereby inhibiting the protein synthesis of protozoa, but the effect is weaker than chloroquine. It can also reduce the oxygen consumption of Plasmodium, inhibit the phosphorylase in Plasmodium and interfere with its sugar metabolism. It also causes agglutination of malarial pigments, but it develops slowly and rarely forms large clumps. In the blood, a certain concentration of Quinine can lead to premature rupture of the parasitized red blood cells, thus preventing the schizont from maturing. Quinine has no effect on the infrared phase and does not cure benign malaria. A long course of treatment can cure P. falciparum, but it has no direct effect on the gametophyte of P. falciparum, so it cannot interrupt transmission. In addition, Quinine has an inhibitory effect on the myocardium, prolongs the refractory period, slows conduction, and weakens its contractility. There is a weak excitatory effect on the uterus during pregnancy.
Effect
Quinine is an important antimalarial drug for the erythrocytic protozoa of P. falciparum that inhibits its reproduction or kills it. Quinine also inhibits myocardial contractility and increases uterine rhythmic contraction.
Quinine COAÂ
Product name
|
Quinine Hydrochloride Dihydrate
|
CAS No.
|
6119-47-7
|
Outer Packing
|
25KG
|
Production date
|
2017.05.24
|
Shelf life
|
2019.05.23
|
Standard adopted
|
BP 2010
|
Items of analysis
|
Specification
|
Results
|
Appearance
|
White, off-white or colorless fine needle crystal
|
Complies
|
Solubility
|
Soluble in water, slightly soluble in ethanol
|
Complies
|
Thin layer chromatography
|
The position, color and size of the points obtained by the experimental solution are consistent with the standard solution.
|
Complies
|
Color reaction
|
Solution green
|
Complies
|
Fluorescence reaction
|
Strong blue fluorescence at 366nm, disappeared after adding 1ml of hydrochloric acid
|
Complies
|
Infrared spectrum
|
The infrared absorption spectrum of this product should be consistent with the reference spectrum (spectrum set 488)
|
Complies
|
Solution appearance
|
The solution is colorless. If there is hydrochloric acid, it is not deeper than GY6.
|
Complies
|
PH
|
6.0-6.8
|
6.4
|
Specific rotation
|
-245°~ -258°
|
-248.3°
|
Other quinine
|
Impurity C ≤ 10.0%,
|
5.17%
|
Any impurities before quinidine ≤5.0%
|
1.12%
|
Sulfate
|
≤500ppm
|
Complies
|
Boron
|
Should be complied
|
Complies
|
Loss on drying
|
6.0%-10.0%
|
7.11%
|
Sulphate ash
|
≤0.1%
|
0.06%
|
Assay (dry product)
|
99.0%-101.0%
|
99.1%
|
Conclusion
|
Qualified
|
Pregnant women are disabled, quinine has oxytocin, can pass the placenta, causing fetal hearing damage and congenital defects of the central nervous system, limbs. Nursing women with caution.
For patients with asthma, atrial fibrillation and other severe heart diseases, glucose-6-phosphate dehydrogenase deficiency, myasthenia gravis, and optic neuritis should be used with caution.
Cardiomyopathy and pregnant women are disabled. Treatment of cerebral malaria with quinine is dangerous, and it is dangerous for people who are allergic to quinine.
Â
Â
Â
Antineoplastic Crude Drug
Nolva-dex
Clo-mid
L-Triiodothyronine(T3)(CAS NO:55-06-1)Â
Trilostane(CAS:13647-35-3)
Â
Weight Loss Drug
Â
L(-)-Carnitine(CAS:541-15-1)
Rimonaban* (CAS: 158681-13-1)
Â
Local Anaesthetic Drug
Benzocaina(CAS NO: 94-09-7)
Tetracaina hydrochloride (CAS:136-47-0)
Procaina hydrochloride (CAS NO:Â Â 51-05-8)
Lidocaina Hydrochloride (CAS NO:Â Â 6108-05-0)
Â
Estrogen Hormone
Progesterone (CAS: 57-83-0)Â
Estradiol (CAS: 50-28-2)Â
Estriol (CAS:50-27-1)
Estradiol valerate (CAS: 979-32-8)
Diethylstilbestrol (CAS: 56-53-1)
Hexestrol (CAS:84-16-2)
Â
others
Proscar (CAS: 98319-26-7)
Avodart (CAS: 164656-23-9)
Androstan-17-ol, 2,3-epithio-17-methyl-, (2a,3a,5a,17b)- (CAS:4267-80-5)
Estra-4,9-diene-3,17-dione (CAS:5173-46-6)
Methoxydienone (CAS:2322-77-2)
Altrenogest (CAS:850-52-2)Â