Scientists discovered how jaundice produces anticancer compounds
In a recent study published in the journal Science Advances, a research team led by Professor Cathie Martin of the John Innes Centre revealed how a plant used in traditional Chinese medicine can produce cancer that may help treat cancer and A compound of liver disease. This plant is known in Chinese medicine as Scutellaria baicalensis and is traditionally used to treat fever, liver and lung discomfort. Previous laboratory cell culture studies have shown that certain compounds known as flavones in the roots of Astragalus membranaceus not only have beneficial antiviral and antioxidant effects, but also kill human cancer cells without affecting healthy cells. In live animal models, flavonoids also stop tumor growth, which provides hope for an effective treatment or even a cure for cancer. The researchers have a relatively good understanding of the flavonoids, but there is a lack of understanding of the beneficial flavonoids found in the roots of Astragalus (such as wogonin and baicalin): the missing -OH (hydroxyl) in their chemical structure allows scientists I can't figure out how they are made in plants. The study's lead author, Professor Cathie Martin, explained: "Many flavonoids are synthesized using a compound called naringenin as a building block. But naringenin possesses a hydroxyl group attached to it, and the production of flavonoids in the roots of Astragalus membranaceus During the process, no known enzyme will remove the hydroxyl group." In collaboration with Chinese scientists, Professor Martin and her team explored the possibility of specific flavonoids (RSFs) in the roots of Astragalus membranaceus via different biochemical pathways. Gradually uncovering the mechanisms involved in the manufacture of RSFs involving new enzymes using different components called chrysin. "We believe that this biosynthetic pathway has recently evolved in the roots of Scutellariae Radix, unlike the classic pathways that produce flavonoids in leaves and flowers, specifically producing chrysin and its derived flavonoids," Professor Martin said. “The understanding of this path will help us to produce these special flavonoids in large quantities, so as to further study their medical potential. The cooperation with Chinese scientists on traditional medicinal plants is very wonderful. The slaughter is because of the work of artemisinin. Since the award of the 2015 Nobel Prize in Medicine, China’s interest in traditional therapies has increased dramatically. It is exciting to consider that plants that have been used for thousands of years in traditional Chinese therapies may lead to effective modern medicines.â€
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