Gene therapy footing orthopedics: rebuild injured bones
Recently, researchers at the Cedars-Sinai Medical Center in the United States successfully repaired severe limb fractures in experimental animals through innovative techniques, helping animals whose bone tissue could not heal themselves to re-grow their own bone tissue. Researchers have now demonstrated the safety and efficacy of this approach for human patients. Combined with ultrasound therapy, stem cell technology and gene therapy technology, this groundbreaking treatment can eventually replace bone tissue transplantation as an effective method to repair severe bone destruction. “The great revolution we have caused in orthopedics is just beginning,†said Dr. Dan Gazit, director of the Seda-Sinai Medical Center's Surgical and Bone Stem Cell Therapy Program, the lead author of the study. “We completed engineering. The organic combination with biology has advanced the progress of bone regeneration engineering, which we believe represents the bright future of regenerative medicine." The corresponding article in this study was published in the latest issue of Science Translational Medicine, entitled "In situ bone tissue engineering via ultrasound-mediated gene delivery to endogenous progenitor cells in mini-pigs." Currently, more than 2 million people worldwide undergo bone transplants every year. These bone grafts are often caused by serious injuries caused by traffic accidents, wars or tumor removal. This damage can create severe fissures between the edges of the fracture, while the fractured edge of the bone is more difficult to bridge independently with respect to other parts of the bone. "For the millions of patients in the world who need bone transplants, the most unfortunate thing is that most of them don't have enough good luck to get bone donor support during the treatment cycle," said Gazit, a professor of surgery at Cedars-Sinai. One of the most serious problems facing bone transplantation today is that there are not enough healthy bones for repair and transplantation. At the same time, the vast majority of patients undergoing bone surgery suffer from prolonged pain and expensive lengthy hospitalizations. In addition, transplanted bones from donors may not be properly integrated or grown on patients with bone damage, leading to failure of the final repair. Round Manway,Round Manway Atmospheric Pressure,Manhole Cover,Hygienic Square Manway Cover Wenzhou Gaoya Light Industry Machinery Co.,ltd. , https://www.hongyafitting.com