Shenzhen accelerates the deployment of precision medical field

Recently, the 2017 Shenzhen International Precision Medical Summit was grandly opened. The newly appointed Guangdong Provincial Party Committee Standing Committee Member, Shenzhen Municipal Party Committee Secretary Wang Weizhong and the Chinese People's Association for Friendship with Foreign Countries Li Xiaolin met with Nobel Prize in Physiology or Medicine, Dr. James Watson and other domestic and foreign experts. To jointly explore the technological and industrial development of cutting-edge fields such as life sciences and precision medicine in Shenzhen. At the same time, the South University of Science and Technology Institute of Precision Medicine, which focuses on cancer-based precision medicine based on genomics and life-health big data, was successfully unveiled and became the “leader” in Shenzhen to explore the “production, study and research” model of precision medicine.

In the past two years, precision medicine has become a hot topic in the field of medical services, and the development of precision medicine is in full swing. In March 2015, the Chinese government held a meeting of experts on precision medicine strategy and proposed to invest 60 billion yuan to develop the precision medical industry by 2030. Subsequently, the “Notice on the issuance of the 2016 National Project Application Guidelines for Key Medical Research Programs, such as Accurate Medical Research,” was issued, and the comprehensive development of the two-child policy was adopted to push precision medicine on the road of rapid development. In this context, the Sixth Session of the Shenzhen Municipal People's Congress will promote the construction of “Healthy Shenzhen” into the government report, and on several occasions, ask relevant departments to support the implementation of the accurate medical plan. It can be said that accelerating the layout of precision medical care has become one of the important measures of Shenzhen medical reform and an important part of Shenzhen's development of future industry.

From the perspective of medical profession, precision medicine is the best method for disease intervention and treatment based on individual genetic characteristics, environment and living habits. It is also a medical model that maximizes the treatment effect and minimizes side effects. It has the characteristics of active discovery for early treatment. Including emerging technologies such as gene sequencing and cell therapy, the development of gene sequencing is relatively mature, and its application in non-invasive prenatal diagnosis plays an important role in reducing the birth defects caused by the increase in maternal age.

The prerequisite for achieving precision medicine is technology. In September 2016, the Shenzhen Municipal Health and Family Planning Commission, the Shenzhen Public Hospital Management Center and Huada Gene jointly established the “Shenzhen Precision Medical Research Institute” (hereinafter referred to as the Precision Medical Research Institute), aiming to adopt “one hospital”. The “N Center” model, signed the characteristic precision medical center, with reference to the construction experience of the national gene bank, together with the major hospitals in Shenzhen to build the “Shenzhen Clinical Biological Sample Resource Library” and “Shenzhen Clinical Biological Sample Information Database”, using big data and wisdom. The model enables precise analysis and diagnosis. At the same time, the combination of genomic technology and clinical diagnosis and treatment will improve the medical level of hospitals in Shenzhen and the health of Shenzhen residents. A few days ago, the Institute of Precision Medicine announced that in the next three years, it will provide free lung cancer gene detection services for all lung cancer patients in Shenzhen, and establish a cohort study covering lung cancer patients in the city, so that each patient can be monitored and used throughout the process. The plan to guide and other services, the first 13 precision medical centers have been implemented, and will gradually cover the city's public hospitals.

It is reported that in order to promote more seed-related projects related to genetic testing, in vitro diagnostics, medical big data , cell therapy, and gene therapy cross-applications, Shenzhen's first precision medical incubator has settled in Luohu Wanxiang City in October last year, with Shenzhen. The core resources of the Municipal Cell Therapy Technology Association, the Shenzhen Cell Quality Testing and Evaluation Public Service Platform and the Shenzhen Gene Detection Clinical Application Public Service Platform have become the professional technical service integration platform for the incubation of precision medical projects in Shenzhen.

Amino Acid

Amino acids are colorless crystals with a melting point of more than 200℃, much higher than that of ordinary organic compounds. α -amino acids have sour, sweet, bitter and fresh taste. Monosodium glutamate and glycine are the most used umami flavoring ingredients. Amino acids are generally soluble in water, acid and alkali solutions, insoluble or slightly soluble in organic solvents such as ethanol or ether. The solubility of amino acids in water varies greatly. For example, tyrosine has the lowest solubility. At 25℃, only 0.045g of tyrosine dissolved in 100g of water, but the solubility of tyrosine is greater in hot water. Lysine and arginine often exist in the form of hydrochloride, because they are easily soluble in water and difficult to crystallize due to deliquescence

(1) Color and color: all kinds of common amino acids are easy to become colorless crystals, and the crystal shape varies with the structure of amino acids. For example, L-glutamic acid is a quadrangular column crystal, and D-glutamic acid is a diamond flake crystal.

(2) Melting point: the melting point of amino acid crystallization is high, generally at 200 ~ 300℃, and many amino acids will decompose into amine and CO2 when reaching or approaching the melting point.

(3) Solubility: Most amino acids are soluble in water. The solubility of different amino acids in water is different, such as lysine, arginine, proline solubility is larger, tyrosine, cysteine, histidine solubility is very small. Various amino acids are soluble in strong bases and acids. But amino acids are insoluble or slightly soluble in ethanol.

(4) Taste sensation: Amino acids and their derivatives have certain taste sensation, such as sour, sweet, bitter and salty. The kinds of taste are related to the kinds and stereoscopic structure of amino acids. Generally speaking, d-type amino acids have sweet taste, and their sweet taste intensity is higher than the corresponding L-type amino acids.

(5) UV absorption characteristics: all kinds of common amino acids have no absorption ability to visible light. But tyrosine, tryptophan and phenylalanine have obvious light absorption in uv region. These three amino acids are found in most proteins, especially tyrosine. Therefore, the uv absorption characteristics at 280nm can be used to quantitatively detect protein content.

An important optical property of amino acids is their absorption of light. All 20 kinds of PR-Aa have light absorption in visible region, and all have light absorption in far ULTRAVIOLET region (<220nm). Only three kinds of AA have light absorption ability in ultraviolet region (near ultraviolet region) (220nm ~ 300nm). These three kinds of amino acids are phenylalanine, tyrosine and tryptophan, because their R group contains benzene ring conjugated double bond system.

The maximum light absorption of phenylalanine AA is 259nm, the maximum light absorption of tyroaa is 278nm, and the maximum light absorption of chroma AA is 279nm. Protein generally contains these three AA residues, so its maximum light absorption is about 280nm wavelength, so it can be used to easily determine the content of protein. Spectrophotometric determination of protein content is based on lambert-Beer law. The absorbance value of protein solution at 280nm is proportional to its concentration.

Amino acids, basic amino,acidic carboxyl

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