The medical "micro-missile" delivers drugs for the first time to the gastric mucus
Release date: 2015-01-23 For micromachines, this is a small but significant step. The micro-engine first shuttled through a living animal and sent the tested gold nanoparticles directly to the stomach of the mouse. Micromachines are expected to revolutionize the diagnosis and treatment of some diseases. For example, miniature "spiders" can repair blood vessels, while micro-robots can move forward in the blood and build medical devices at the site of the disease. But to this day, these devices have been tested in cell samples in the laboratory rather than in living animals. Wei Gao and colleagues from the University of California, Berkeley have just changed everything. They put chemically driven micromachines into mice. These mechanical energy reacts chemically with gastric acid into a miniature "torpedo", which then stays in the mucus in the stomach and delivers the drug to treat peptic ulcers, gastritis or stomach cancer. They are a type of 20 micron long, tapered polymer tube wrapped in zinc. In gastric acid, zinc chemically reacts to generate hydrogen bubbles. These bubbles are squeezed from the wider end of the tube, thereby pushing the tube to move in the stomach acid. “Most of the previously reported self-propelled engines rely on non-biocompatible chemical fuels such as hydrogen peroxide,†Gao said. In contrast, zinc-encapsulated polymers are non-toxic, making them more suitable for use in living animals. These engines travel through gastric acid at a rate of 60 microns per second. Gao and colleagues believe that this is enough to allow the micromachine to stay in the mucus in the stomach wall and unload the drug. Source: Chinese Journal of Science Double Packed Yellow Waxy Corn Cob The most common waxy and sweet corn market, waxy corn nutrient content is higher than ordinary corn, contains 70-75% starch (and almost all amylose), more than 10% protein, 4-5% fat and 2% multivitamin, has more grain, VA, VB1, VB2 than rice protein, fat and VB2 highest content. Yellow corn also contains carotenoids like rice and wheat. The molecular weight of glutinous corn starch is more than 10 times smaller than that of ordinary corn. The starch makes glutinous rice sticky and soft, which is softer than that of ordinary hard corn. It has more than 20 percent more digestibility than regular corn and is suitable for people with irregular teeth. At the same time, the amylose (a polysaccharide) content is very high, not suitable for diabetics.
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