Pain relievers such as ibuprofen may increase the risk of heart disease in individuals
Pain relievers such as ibuprofen may increase the risk of heart disease in individuals April 05, 2017 Source: Bio Valley Drugs such as ibuprofen and aspirin are non-steroidal anti-inflammatory drugs (NSAIDs) that are found everywhere in pharmacies and supermarkets, but health care providers sometimes believe that these drugs can cause chronic health problems. Such as kidney disease, high blood pressure or heart failure. NSAIDs can also be very dangerous with other drugs, such as many types of blood pressure and blood thinning drugs (warfarin and aspirin). Two recent studies have clarified heart-related side effects induced by NSAIDs. One study found that patients with NSAIDs had an increased risk of heart failure, while another study showed that intake of NSAIDs increased heartbeat. The risk of sudden arrest. Heart failure is mainly caused by shortness of breath, fluid retention, swelling of the legs and fatigue. This is because the heart fails to effectively pump the blood to the body. There are many reasons for heart failure, including heart attack and high blood pressure. And excessive alcohol intake and so on. Many studies have reminded people that over-the-counter drugs are not without risk. These anti-inflammatory analgesics are usually not sold in retail stores, but they are limited to prescription purchases or after pharmacy counters. How do these drugs work? NSAIDs are often used to relieve pain, doctors can prescribe, and the drug can be purchased at pharmacy counters or supermarket counters; these drugs can be used to treat a range of pain and inflammation-related diseases, including multiple types of joints. The usefulness, effectiveness, and safety of inflammation, headache, musculoskeletal injury, and dysmenorrhea often make these drugs widely used by many people. NSAIDs can act by inhibiting enzymes called cyclooxygenase 1 (COX-1) and cyclooxygenase 2 (COX-2) in the body, which can participate in a series of intrinsic pathways, leading to The production of prostaglandins, which can promote inflammation in the body and increase the feeling of pain. At the same time, prostaglandins can protect the gastric mucosa from damage by reducing the production of acid and increasing the secretion of mucus. Therefore, inhibition of prostaglandins will reduce the effect of protecting the body, which is why patients with frequent use of anti-inflammatory drugs often suffer from stomach. The cause of the ulcer. In addition, drugs similar to ibuprofen and aspirin are non-selective and can inhibit the function of all COX enzymes; COX-1 can mediate gastrointestinal, renal and hemagglutination, while COX-2 is inflammatory. It is induced in the state of tissue damage, which is why blocking the function of the COX-2 pathway reduces inflammatory effects such as fever, edema, and body pain. Animal studies have shown that blocking COX-2 and subsequent prostaglandin production may have an adverse effect on increased intravascular blood coagulation and also reduce the ability of heart repair after a heart attack. Earlier in 2000, a large number of studies found that the ingestion of selective COX-2 inhibitors was directly associated with adverse cardiac events, such as heart attacks and strokes, which led to the withdrawal of the drugs valdecoxib and rofecoxib. Market; in Australia, there are currently very few COX-2 inhibitors, including the drugs celecoxib and meloxicam; COX-2 inhibitors are commonly used in patients who require non-steroidal anti-inflammatory drugs, but these Patients have a history of stomach upset or stomach ulcers, or patients are considered to be at higher risk of developing gastric ulcers. Risk of heart failure Non-steroidal anti-inflammatory drugs are directly related to blood pressure and sodium and fluid retention in the body, and these effects are revealed before the patient is diagnosed with heart failure, and it also causes the disease condition of patients who have suffered from heart failure. Aggravated. In a study published in the September 2016 issue of BMJ, the researchers studied 92,163 patients admitted to hospital for heart failure and found that patients who received NSAIDs two weeks before admission had a risk of heart failure. Increase by 19%. At the same time, the researchers also found a correlation between NSAIDs intake and increased heart failure in many previous studies. For example, a study conducted by Australian researchers in 2000 showed that about 20% of patients with heart failure were due to recent photos. Induced by NSAIDs drugs. Risk of sudden cardiac arrest In a study published in the European Heart Journal, researchers from the University of Copenhagen described the link between future intake of NSAIDs and cardiac safety. In the article, researchers collected 30,000 heartbeats between 2001 and 2010. With data on patients discontinued, the researchers found that approximately 3,500 of these patients had taken NSAIDs during the first 30 days of cardiac arrest. Intake of NSAID increases the risk of cardiac arrest in 31% of individuals, while commonly used non-selective NSAIDs, such as fustatin tablets and ibuprofen, cause 50% and 31% of cardiac arrest, respectively. A large part of cardiac arrest occurs because of clot formation in the heart's arteries or rupture of plaque formation. Drug NSAIDs may increase the risk of cardiac arrest by increasing the body's blood pressure, which can form blood clots and block Break the blood vessels in the heart. For individuals who don't understand heart disease and don't have any risk factors for heart disease, the researchers say, we need to emphasize that short-term use of these anti-inflammatory drugs may slightly increase the risk of heart-related diseases. However, these latest studies should not cause panic in the short-term or low-dose intake of NSAIDs in the community. But in the high burden of heart disease and a variety of heart disease risk factors, such as high blood pressure, obesity and diabetes, ensuring individualized use of NSAIDs may maximize the benefits to users and reduce the risk of drug intake. . Finally, the researchers believe that in the future these anti-inflammatory drugs can be prescribed by holding a doctor or buying behind a pharmacy counter. China Extract Powder For Use As Dietary Supplement Extract Powder, Extract Powder Manufacturer Shaanxi Kang New Pharmaceutical co., Ltd. , https://www.bodybuildingoil.com