Vitamin C can also treat leukemia
Vitamin C can also treat leukemia September 5, 2016 Source: WuXi PharmaTech Vitamin C deficiency often occurs in cancer patients and often increases the difficulty of treatment. Nowadays, studies have shown that the lack of vitamin C may indeed reduce the effectiveness of certain types of cancer drugs. At the same time, clinical trials based on this finding have also been initiated to test the adjuvant effect of vitamin C on the treatment of some malignant hematological tumors. Recently, scientists from institutions such as Van Andel Institute of the United States and Rigshospitalet Hospital of Denmark found in vitro that vitamin C can significantly enhance the anti-tumor effect of an epigenetic drug 5-aza-CdR. When the two are used together, the inhibitory effect on cancer cell lines such as colorectal cancer, breast cancer, leukemia, and hepatocellular carcinoma is significantly enhanced, and vitamin C increases the proportion of apoptosis of the above cancer cells by 1.5 to 2.2 times. The findings were published in the recent issue of PNAS. 5-aza-CdR is a DNA methyltransferase inhibitor (DNMTis) that has the effect of inhibiting DNA methylation and increasing partial gene expression. Vitamin C can enhance this effect. As a coenzyme of the DNA demethylase TET, vitamin C promotes the demethylation of the long tandem repeat (LTR) of the endogenous retrovirus (ERV) gene that is "parasitic" in the cancer cell genome by TET. 5-methylcytosine (5 mC) was converted to 5-hydroxymethylcytosine (5hmC). This further promotes the bidirectional transcription of the ERV gene and generates a large amount of double-stranded RNA of ERV, thereby inducing an antiviral reaction inside the cancer cell, which is manifested by an increase in the expression of antiviral-related proteins such as interferon and the frequency of apoptosis. Inspired by this result, Rigshospitalet Hospital has initiated a pilot clinical trial to test the proliferation of bone marrow in combination with vitamin C and another similar DNA methyltransferase inhibitor drug, azacitidine. Efficacy of two malignant hematological tumors of abnormal syndrome (MDS) and acute myeloid leukemia (AML). “If this pilot clinical trial is successful, we would like to further launch a larger clinical trial to verify whether it can be used as a direct, cost-effective and effective means of improving the efficacy of current MDS and AML treatments,†One of the co-authors, Professor Peter A. Jones of the Van Andel Institute, said: "At the same time, we must remind patients to be patient and cautious about this. Regarding whether vitamin C has an adjuvant treatment, there is only one vitamin C and A combination of aza-cytidine and a combination of placebo and azacytidine gives an answer. We also emphasize that this conclusion is limited to the efficacy of azacytidine for MDS and AML and cannot be generalized. To other cancers and other therapies." “This combination therapy has potential, but we need to do more to prove its effectiveness and safety,†said the author of the article and the leader of the clinical trial, Kirsten Gr at Rigshospitalet Hospital. Nb? Professor K said: "I am very excited to think that there may be such a simple and ingenious way to help treat MDS and AML. However, as a doctor, I strongly recommend that patients wait for the test results to come out before making a decision, and must Discuss possible dietary and nutritional supplement interventions with your doctor." Kn95 5 Layers 3D Mask,Kn95 Protective Respirator,Filter Cotton Kn95 Face Mask,Kn95 5 Layers Fold Flat Respirator Jiangmen anjian biotechnology co. LTD , https://www.jmanjianmask.com